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Composition
of Pueraria Mirifica
Our researcher has started research
on Pueraria Mirifica since 1991 and then later on Butea Superba.
The compounds that make Pueraria Mirifica different from
any other phytoestrogen containing plants in the Family
Leguminosae are Miroestrol and Deoxymiroestrol, which
possess highest estrogenic activity among the known phytoestrogens
due to structural similarity to estradiol, Miroestrol
was actually the first compound isolated from this plant
by a group of German chemists in 1940, but the plant had
been mistakenly reported then as Butea Superba. It was
later on classified as a new plant called Pueraria mirifica
Airy Shaw et Suvatabhandu.
The isolation and identification of deoxymiroestrol from
the root of Pueraria Mirifica has just been reported in
the February 2000 issue of the Journal of Natural Products,
The authors proposed that since deoxymiroestrol is easily
oxidized to miroestrol, deoxymiroestrol, not the previously
reported miroestrol, is more likely to be the actual chemical
constituent of Pueraria Mirifica.
However, it is very likely that the two phytoestrogens
coexist in the root of this plant. As shown below, the
chemical structures of two compounds are very similar
to that of estradiol, the main human estrogen.
In addition to miroestrol and deoxymiroestrol, Pueraria
Mirifica also contains other chemicals that belong to
isoflavone and coumestran groups of phytoestrogens, e.g.,
Genistein, Daidzein, Daidzin, Genistin, and Coumestrol
that are usually found in soybeans (Table 1). However,
the estrogenic activity of Miroestrol and Deoxymiroestrol
is much more potent than that of soy isoflavones.
Table
1: Chromene, Isoflavonoid and Coumestan derivatives
in Pueraria Mirifica |
Chromene |
Isoflavones |
Isoflavones
glycosides |
Coumestan |
Miroestrol |
Daidzein |
Daidzin |
Coumestrol |
Deoxymiroestrol |
Genistein |
Genistin |
Mirificoumestan |
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Kwakhurin |
Mirificin |
Mirificoumestan
glycol |
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Kwakhurin hydrate |
Puerarin |
Mirificoumestan
hydrate |
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Puerarin-6” monoacetate
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What is benefit effects
of Chemical composition from Pueraria mirifica ?
While Soya and Alfafa contains low amount and low estrogenic
of the phytoestrogens, many researches pointed out the
benefit effects of those chemicals, especially to act
as a Potent Anti-Breast Cancer, Anti-Prostate Cancer,
Anti-Colon Cancer, Anti-Cardio-Vascular disease via the
reduction of blood cholesterol and also Anti-Menopausal
Syndrome. The phytoestrogens in the Pueraria Mirifica (White Kwao Krua)
is more concentrated and higher efficacy. By this distinguish
property, biotechnology application has shown up for this
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